After doing some research, I've found that the best route to drive from Denver to Seattle during winter is to take I-25 N and I-90 W, which is the most straightforward and safe route. It's important to keep in mind that winter conditions can be unpredictable, so be sure to check weather forecasts and road conditions regularly. It's also a good idea to equip your vehicle with winter tires, carry an emergency kit, and plan plenty of time for rest stops. Don't rush the trip, safety should always be your priority. Lastly, enjoy the scenic beauty of this route, as it offers spectacular views of the Rocky Mountains and the Pacific Northwest.